Tirzepatide
Dual GIP / GLP-1 Agonist | β-Cell Signalling Research
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Third-party Tested
COA Verified
Cold Storage
Same-day DeliveryFor research use only. Analytical reference material for in vitro work by qualified researchers. Learn more
Active Batch
TIR-202602-J1
Purity
99.269%
Third-party TestedCOA VerifiedCold StorageSame-day DeliveryTirzepatide is a synthetic dual agonist peptide targeting both the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. With a molecular weight of 4813 g/mol and molecular formula C225H348N48O68, Tirzepatide incorporates a C20 fatty diacid moiety enabling extended pharmacokinetic profiles, and has been extensively studied in published research for its incretin receptor binding mechanisms, beta-cell signaling pathways, and glucose-dependent insulin secretion models. Peer-reviewed literature has examined Tirzepatide's biased agonism at the GIP receptor, its comparative efficacy in metabolic pathway assays versus selective GLP-1 receptor agonists, and its effects on lipid metabolism and adipose tissue signaling in preclinical models. This compound is provided as a research reagent for incretin biology and metabolic pathway studies. It is not intended for unauthorized human or veterinary use, and no claims regarding glycemic control or weight management are made or implied.
Tirzepatide is a synthetic dual agonist peptide targeting both the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. With a molecular weight of 4813 g/mol and molecular formula C225H348N48O68, Tirzepatide incorporates a C20 fatty diacid moiety enabling extended pharmacokinetic profiles, and has been extensively studied in published research for its incretin receptor binding mechanisms, beta-cell signaling pathways, and glucose-dependent insulin secretion models. Peer-reviewed literature has examined Tirzepatide's biased agonism at the GIP receptor, its comparative efficacy in metabolic pathway assays versus selective GLP-1 receptor agonists, and its effects on lipid metabolism and adipose tissue signaling in preclinical models. This compound is provided as a research reagent for incretin biology and metabolic pathway studies. It is not intended for unauthorized human or veterinary use, and no claims regarding glycemic control or weight management are made or implied.
For Research Purposes Only
By purchasing this product, you acknowledge that you are a qualified researcher. Not for human or animal consumption.
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2D Structure
Known Synonyms
Identifiers
Molecular Formula
C225H348N48O68
InChIKey
AAPYRSPHYSKGIS-MCNPHUAVSA-N
InChI
Computed Properties
2D Structure
Known Synonyms
Identifiers
Computed Properties
Tirzepatide — Research Reference
A dual GIP and GLP-1 receptor agonist — a widely cited reference compound in β-cell signalling and incretin SAR research.
What is Tirzepatide?
Tirzepatide is a 39-amino-acid synthetic peptide engineered as a dual agonist at both the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor. It is one of the most extensively published dual-incretin reference compounds of the past decade, with peer-reviewed studies spanning β-cell signalling, receptor-coupled cAMP assays, and structure-activity relationship work across the incretin class. Tirzepatide carries a C20 fatty-diacid side chain that binds serum albumin and extends molecular stability under physiological conditions — a structural feature shared with several long-acting peptide reference compounds. Noxa Labs supplies tirzepatide as a Janoshik-tested analytical reference material for in vitro laboratory research only.
Mechanism in research literature
GIP and GLP-1 are the two principal incretin hormones — gut-derived peptides whose receptors are densely expressed on pancreatic β-cells. Tirzepatide engages both receptors with a balanced agonist profile, with research-literature interest centred on its β-cell signalling output (cAMP accumulation, glucose-stimulated insulin secretion in INS-1 and primary islet assays) and its differential receptor bias compared to single-receptor GLP-1 reference compounds. Published cell-culture work since 2018 has profiled the compound's downstream PKA and Epac2 signalling, β-arrestin recruitment, and receptor internalisation kinetics. The molecule was specifically engineered to balance affinity at the two receptors, which differentiates it mechanistically from single-receptor GLP-1 reference compounds like semaglutide.
Documented research applications
Tirzepatide has been studied in research contexts including pancreatic β-cell function assays, glucose-stimulated insulin secretion in INS-1 and primary islet cultures, adipocyte differentiation and lipolysis assays in 3T3-L1 systems, hepatic lipid metabolism cell-culture research, and comparative incretin receptor pharmacology. It is among the most actively published dual-incretin reference compounds in the current literature. Researchers comparing dual versus single incretin receptor engagement frequently study tirzepatide alongside semaglutide and the newer triple-receptor reference compound retatrutide. All three are available from Noxa Labs as analytical reference materials.
Reconstitution
Reconstitute lyophilised tirzepatide with bacteriostatic water at a concentration appropriate to your assay. A common starting concentration is 5 mg/mL for a 10 mg vial reconstituted with 2 mL BAC water. Direct the diluent against the side wall of the vial; do not inject directly onto the lyophilate. Swirl gently to dissolve.
Storage & stability
Store lyophilised tirzepatide refrigerated at 2–8 °C for long-term stability. Reconstituted tirzepatide should be stored at 2–8 °C and used within 4 weeks. Do not freeze reconstituted solution unless specifically validated for your assay.
Availability in the Philippines
Tirzepatide ships from Noxa Labs Metro Manila inventory with cold-chain packaging. Nationwide delivery to Luzon, Visayas, and Mindanao destinations in 2–3 business days.
Frequently asked questions
All Noxa Labs products are supplied strictly as analytical reference materials for qualified in vitro research. They are not pharmaceutical products, food supplements, or substances for human or animal consumption.
Pair Tirzepatide with these peptides
Verified compounds researchers commonly add to their workflow.
BAC Water
3 ml
Retatrutide
10 mg
Semaglutide
10 mg
BPC-157
10 mg
CJC-1295 (No DAC) + Ipamorelin (Blend)
10 mg
GHK-Cu
100 mg
BAC Water
3 ml
Retatrutide
10 mg
Semaglutide
10 mg
BPC-157
10 mg
