GHK-Cu
Copper-Binding Tripeptide | Skin & Tissue Remodeling Studies
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Cold Storage
Same-day DeliveryFor research use only. Analytical reference material for in vitro work by qualified researchers. Learn more
Active Batch
GHK-202602-J1
Purity
99.88%
Third-party TestedCOA VerifiedCold StorageSame-day DeliveryGHK-Cu (Copper Peptide GHK-Cu) is a naturally occurring tripeptide-copper complex with the sequence glycyl-L-histidyl-L-lysine bound to a copper(II) ion. With a molecular weight of 742.3 g/mol and CAS number 130120-56-8, GHK-Cu has been identified in human plasma, saliva, and urine, and has been extensively studied in peer-reviewed literature for its involvement in extracellular matrix remodeling, collagen synthesis signaling, and metalloproteinase regulation. Preclinical research has investigated GHK-Cu's role in fibroblast activity modulation, decorin expression, and antioxidant enzyme upregulation pathways. This compound is provided solely as a reference standard and research reagent for in vitro laboratory use. It is not intended for human or veterinary use, and no therapeutic or cosmetic claims are made or implied.
GHK-Cu (Copper Peptide GHK-Cu) is a naturally occurring tripeptide-copper complex with the sequence glycyl-L-histidyl-L-lysine bound to a copper(II) ion. With a molecular weight of 742.3 g/mol and CAS number 130120-56-8, GHK-Cu has been identified in human plasma, saliva, and urine, and has been extensively studied in peer-reviewed literature for its involvement in extracellular matrix remodeling, collagen synthesis signaling, and metalloproteinase regulation. Preclinical research has investigated GHK-Cu's role in fibroblast activity modulation, decorin expression, and antioxidant enzyme upregulation pathways. This compound is provided solely as a reference standard and research reagent for in vitro laboratory use. It is not intended for human or veterinary use, and no therapeutic or cosmetic claims are made or implied.
For Research Purposes Only
By purchasing this product, you acknowledge that you are a qualified researcher. Not for human or animal consumption.
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2D Structure
Known Synonyms
Identifiers
Molecular Formula
C28H48CuN12O8
InChIKey
RIPDSRHLQNAZOH-XTQNZXNBSA-N
InChI
Computed Properties
2D Structure
Known Synonyms
Identifiers
Computed Properties
GHK-Cu — Research Reference
A naturally occurring copper-binding tripeptide (Gly-His-Lys) extensively studied in skin biology, ECM remodelling, and gene-expression research.
What is GHK-Cu?
GHK-Cu is the copper(II) complex of the tripeptide Glycyl-L-Histidyl-L-Lysine. The parent peptide (GHK) was first identified in human plasma in 1973 by Loren Pickart and has since become one of the most studied small peptides in research literature, with over 500 published papers spanning dermatology research, wound-healing models, extracellular matrix remodelling, anti-inflammatory pathway studies, and gene-expression profiling. The copper-bound form (GHK-Cu) is the biologically active complex described in most of that literature — copper binding stabilises the peptide and is integral to its observed effects in cell-culture and rodent studies.
Mechanism in research literature
Research literature describes GHK-Cu as engaging multiple pathways relevant to extracellular matrix remodelling and tissue homeostasis. Documented effects in cell-culture include upregulation of collagen and glycosaminoglycan synthesis in dermal fibroblast cultures, modulation of metalloproteinase expression (notably MMP-2), suppression of pro-inflammatory cytokine production, and gene-expression changes affecting hundreds of human genes as profiled in cDNA microarray studies. The copper transport activity of GHK is also implicated in antioxidant pathway support and DNA-damage response modulation. A comprehensive review by Pickart and Margolina (Int J Mol Sci, 2018) synthesises the mechanistic literature; relevant citations are linked in the Studies tab.
Documented research applications
GHK-Cu has been studied in research contexts including dermal regeneration models, hair follicle biology, dermal fibroblast cultures, in vitro skin equivalent models, and inflammatory pathway research. Cosmetic formulation research has examined GHK-Cu extensively in topical applications. We supply GHK-Cu strictly as a research reference material — not as a finished cosmetic or topical product. The compound also appears in research-use blends with BPC-157 and TB-500 (see our Glow Blend product page) for laboratories interested in studying combined effects on dermal models.
Reconstitution
GHK-Cu has a distinctive deep blue colour due to the copper(II) complex — this is normal and expected. Reconstitute with bacteriostatic water for laboratory work. A common starting concentration is 50 mg/mL for a 50 mg vial reconstituted with 1 mL BAC water, or scale as appropriate to your assay. Protect the reconstituted solution from light during handling.
Storage & stability
Store lyophilised GHK-Cu refrigerated at 2–8 °C, protected from light. The reconstituted solution should be kept at 2–8 °C and used within 30 days. The blue copper colour should remain consistent; significant colour change may indicate degradation.
Availability in the Philippines
GHK-Cu ships from Noxa Labs Metro Manila inventory in light-protective vials with cold-chain packaging. Nationwide delivery in 2–3 business days.
Frequently asked questions
All Noxa Labs products are supplied strictly as analytical reference materials for qualified in vitro research. They are not pharmaceutical products, food supplements, or substances for human or animal consumption.
Pair GHK-Cu with these peptides
Verified compounds researchers commonly add to their workflow.
BAC Water
3 ml
BPC-157
10 mg
TB-500
10 mg
CJC-1295 (No DAC) + Ipamorelin (Blend)
10 mg
Melanotan II
10 mg
NAD+
100 mg
BAC Water
3 ml
BPC-157
10 mg
TB-500
10 mg
CJC-1295 (No DAC) + Ipamorelin (Blend)
10 mg
