TB-500
Synthetic Thymosin β-4 Fragment | Tissue Repair & Inflammation Studies
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Third-party Tested
COA Verified
Cold Storage
Same-day DeliveryFor research use only. Analytical reference material for in vitro work by qualified researchers. Learn more
Active Batch
TB5-202602-J1
Purity
99.008%
Third-party TestedCOA VerifiedCold StorageSame-day DeliveryTB-500 is a synthetic analog of the 43-amino-acid active region of thymosin beta-4, a naturally occurring protein involved in actin sequestration and cytoskeletal organization. With a molecular weight of 889.0 g/mol and CAS number 885340-08-9, TB-500 has been studied in preclinical models for its interaction with actin polymerization pathways, cell migration signaling, and inflammatory cytokine modulation. Published research has investigated TB-500's role in endothelial cell differentiation, keratinocyte migration assays, and cardiac progenitor cell signaling pathways. This compound is provided exclusively as a lyophilized research reagent for laboratory use. It is not intended for human or veterinary use, and no claims regarding wound healing or therapeutic efficacy are made or implied.
TB-500 is a synthetic analog of the 43-amino-acid active region of thymosin beta-4, a naturally occurring protein involved in actin sequestration and cytoskeletal organization. With a molecular weight of 889.0 g/mol and CAS number 885340-08-9, TB-500 has been studied in preclinical models for its interaction with actin polymerization pathways, cell migration signaling, and inflammatory cytokine modulation. Published research has investigated TB-500's role in endothelial cell differentiation, keratinocyte migration assays, and cardiac progenitor cell signaling pathways. This compound is provided exclusively as a lyophilized research reagent for laboratory use. It is not intended for human or veterinary use, and no claims regarding wound healing or therapeutic efficacy are made or implied.
For Research Purposes Only
By purchasing this product, you acknowledge that you are a qualified researcher. Not for human or animal consumption.
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2D Structure
Known Synonyms
Identifiers
Molecular Formula
C38H68N10O14
InChIKey
ADKDNDYYIZUVCZ-ZQNQAVPYSA-N
InChI
Sequence
LKKTETQ
Computed Properties
2D Structure
Known Synonyms
Identifiers
Computed Properties
TB-500 — Research Reference
A synthetic 17-amino-acid peptide based on the active fragment of Thymosin Beta-4, widely studied in tissue-repair and angiogenesis models.
What is TB-500?
TB-500 is a synthetic research peptide derived from the active region of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino-acid protein found in nearly all human and animal cell types. The 17-residue active fragment retains the actin-binding properties of the parent protein while being far more practical to synthesise and handle as a reference material. TB-500 has been studied in over 100 peer-reviewed publications since the early 2000s in contexts including tendon and ligament injury models, dermal wound-healing assays, ocular surface repair models, and cardiac ischaemia/reperfusion studies. It is supplied as a lyophilised powder and is hygroscopic, requiring careful handling on the bench.
Mechanism in research literature
The Thymosin Beta-4 protein from which TB-500 is derived binds G-actin and regulates actin sequestration — one of the most fundamental mechanisms of cytoskeletal control in eukaryotic cells. TB-500 retains this binding capacity through a conserved seven-residue actin-binding motif (LKKTETQ). Research literature describes the resulting effects on cell migration, differentiation, and angiogenesis in injury models. Studies have additionally reported upregulation of VEGF expression and modulation of inflammatory cytokine profiles in cell-culture systems exposed to TB-500. Mechanistic reviews are available in journals including Annals of the New York Academy of Sciences and Expert Opinion on Biological Therapy; relevant studies are linked in the Studies tab on this page.
Documented research applications
Documented research contexts include tendinopathy and ligament injury rodent models, dermal wound healing in mouse and rat models, corneal epithelial repair, cardiac infarct models, and in vitro endothelial cell migration assays. TB-500 is also commonly paired with BPC-157 in musculoskeletal injury research — both compounds are described in the literature as cytoprotective, and combination protocols appear in tendon-repair studies. Our BPC-157/TB-500 Wolverine Blend is a research-use blend of the two for laboratories that prefer a single reconstitution.
Reconstitution
Reconstitute lyophilised TB-500 with bacteriostatic water. A common working concentration for cell-culture assays is 1 mg/mL: add 2 mL of BAC water to a 2 mg vial. Allow the vial to equilibrate to room temperature before adding diluent. Direct the diluent against the side wall of the vial — not directly onto the lyophilate — and swirl gently until fully dissolved.
Storage & stability
Store lyophilised TB-500 refrigerated at 2–8 °C protected from light for long-term stability. Reconstituted TB-500 should be stored at 2–8 °C and used within the window specified on the batch COA (typically up to 4 weeks). Avoid repeated freeze-thaw cycles, which degrade peptide integrity.
Availability in the Philippines
TB-500 ships from Noxa Labs Metro Manila inventory with full cold-chain packaging. Same-day dispatch on weekday orders before 2 PM PHT; nationwide arrival in 2–3 business days.
Frequently asked questions
All Noxa Labs products are supplied strictly as analytical reference materials for qualified in vitro research. They are not pharmaceutical products, food supplements, or substances for human or animal consumption.
Pair TB-500 with these peptides
Verified compounds researchers commonly add to their workflow.
BAC Water
3 ml
BPC-157
10 mg
GHK-Cu
100 mg
CJC-1295 (No DAC) + Ipamorelin (Blend)
10 mg
Melanotan II
10 mg
NAD+
100 mg
BAC Water
3 ml
BPC-157
10 mg
GHK-Cu
100 mg
CJC-1295 (No DAC) + Ipamorelin (Blend)
10 mg
