PT-141
Melanocortin Receptor Agonist | Melanocortin Receptor Research
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Third-party Tested
COA Verified
Cold Storage
Same-day DeliveryFor research use only. Analytical reference material for in vitro work by qualified researchers. Learn more
Active Batch
PT1-202602-J1
Purity
99.864%
Third-party TestedCOA VerifiedCold StorageSame-day DeliveryPT-141 (Bremelanotide) is a synthetic cyclic heptapeptide derived from Melanotan II, functioning as a selective agonist of the melanocortin-4 receptor (MC4R). With a molecular weight of 1025.2 g/mol and CAS number 189691-06-3, PT-141 has been studied in published research for its melanocortin receptor binding profile, central nervous system signaling pathways, and dopaminergic system interactions in preclinical models. Peer-reviewed literature has examined PT-141's receptor selectivity versus other melanocortin analogs, its effects on hypothalamic neuron activation in animal models, and its pharmacokinetic profile in various assay systems. This compound is provided exclusively as a research reagent for receptor binding and signaling studies. It is not intended for human or veterinary use, and no claims regarding libido, sexual function, or any physiological effects are made or implied.
PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide derived from Melanotan II, functioning as a selective agonist of the melanocortin-4 receptor (MC4R). With a molecular weight of 1025.2 g/mol and CAS number 189691-06-3, PT-141 has been studied in published research for its melanocortin receptor binding profile, central nervous system signaling pathways, and dopaminergic system interactions in preclinical models. Peer-reviewed literature has examined PT-141's receptor selectivity versus other melanocortin analogs, its effects on hypothalamic neuron activation in animal models, and its pharmacokinetic profile in various assay systems. This compound is provided exclusively as a research reagent for receptor binding and signaling studies. It is not intended for human or veterinary use, and no claims regarding libido, sexual function, or any physiological effects are made or implied.
For Research Purposes Only
By purchasing this product, you acknowledge that you are a qualified researcher. Not for human or animal consumption.
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2D Structure
Known Synonyms
Identifiers
Molecular Formula
C50H68N14O10
InChIKey
FFHBJDQSGDNCIV-MFVUMRCOSA-N
InChI
Sequence
XDHFRWK
Computed Properties
2D Structure
Known Synonyms
Identifiers
Computed Properties
PT-141 — Research Reference
A cyclic heptapeptide melanocortin receptor agonist (also known as bremelanotide), widely studied in melanocortin receptor pharmacology research.
What is PT-141?
PT-141 — also known as bremelanotide — is a synthetic cyclic heptapeptide derived from the α-MSH lineage. It engages melanocortin receptors with a preference for MC3R and MC4R, and has been studied in published research covering melanocortin pathway pharmacology, MC3R/MC4R signalling assays, and structure-activity relationship work across the cyclic melanocortin agonist family.
Mechanism in research literature
PT-141 binds melanocortin receptors with a selectivity profile distinct from the natural α-MSH ligand — published cell-culture work characterises preferential agonism at MC4R relative to MC1R, with binding affinity ratios shifted by the cyclised heptapeptide backbone. Compared with the pan-melanocortin agonist Melanotan II, PT-141's reduced MC1R binding produces a markedly different signalling profile in melanocyte culture assays. This receptor-selectivity profile is the defining feature of the molecule and the most-cited subject of research literature on the compound.
Documented research applications
Documented research contexts include MC3R/MC4R signalling assays, melanocortin receptor binding studies, comparative melanocortin pharmacology against Melanotan II and α-MSH, and SAR research across the cyclic melanocortin family.
Reconstitution
Reconstitute lyophilised PT-141 with bacteriostatic water. Common concentrations are 10 mg/mL for a 10 mg vial in 1 mL BAC water. Direct diluent against the vial wall and swirl gently.
Storage & stability
Store lyophilised at 2–8 °C. Reconstituted solution at 2–8 °C, used within 4 weeks.
Frequently asked questions
All Noxa Labs products are supplied strictly as analytical reference materials for qualified in vitro research. They are not pharmaceutical products, food supplements, or substances for human or animal consumption.
Pair PT-141 with these peptides
Verified compounds researchers commonly add to their workflow.
BAC Water
3 ml
CJC-1295 (No DAC) + Ipamorelin (Blend)
10 mg
Melanotan II
10 mg
BPC-157
10 mg
GHK-Cu
100 mg
NAD+
100 mg
BAC Water
3 ml
CJC-1295 (No DAC) + Ipamorelin (Blend)
10 mg
Melanotan II
10 mg
BPC-157
10 mg
