Melanotan II
α-MSH Analog | Melanocortin & Pigmentation Research
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BAC Water 10 ML included
Automatically added with 10 mg
Third-party Tested
COA Verified
Cold Storage
Same-day DeliveryFor research use only. Analytical reference material for in vitro work by qualified researchers. Learn more
Active Batch
MT2-202602-J1
Purity
99.907%
Third-party TestedCOA VerifiedCold StorageSame-day DeliveryMelanotan II is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH), designed as a non-selective agonist of melanocortin receptors MC1R through MC5R. With a molecular weight of 1646.8 g/mol and CAS number 75921-69-6, Melanotan II has been the subject of published research examining melanocortin receptor binding affinity, downstream cAMP signaling cascades, and melanogenesis pathway activation in cell-based assays. Preclinical studies have investigated Melanotan II's receptor selectivity profile, its interaction with hypothalamic feeding circuits via MC4R, and its role in lipid metabolism research models. This compound is supplied solely as a reference standard for melanocortin receptor research. It is not intended for human or veterinary use, and no claims regarding pigmentation, appetite, or any physiological effects are made or implied.
Melanotan II is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH), designed as a non-selective agonist of melanocortin receptors MC1R through MC5R. With a molecular weight of 1646.8 g/mol and CAS number 75921-69-6, Melanotan II has been the subject of published research examining melanocortin receptor binding affinity, downstream cAMP signaling cascades, and melanogenesis pathway activation in cell-based assays. Preclinical studies have investigated Melanotan II's receptor selectivity profile, its interaction with hypothalamic feeding circuits via MC4R, and its role in lipid metabolism research models. This compound is supplied solely as a reference standard for melanocortin receptor research. It is not intended for human or veterinary use, and no claims regarding pigmentation, appetite, or any physiological effects are made or implied.
For Research Purposes Only
By purchasing this product, you acknowledge that you are a qualified researcher. Not for human or animal consumption.
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2D Structure
Known Synonyms
Identifiers
Molecular Formula
C50H69N15O9
InChIKey
JDKLPDJLXHXHNV-MFVUMRCOSA-N
InChI
Sequence
XDHFRWK
Computed Properties
2D Structure
Known Synonyms
Identifiers
Computed Properties
Melanotan II — Research Reference
A synthetic cyclic heptapeptide α-MSH analogue, the most-studied research peptide in melanocortin pathway and melanogenesis literature.
What is Melanotan II?
Melanotan II (MT-II) is a synthetic cyclic heptapeptide analogue of α-melanocyte-stimulating hormone (α-MSH). Originally developed in the 1980s at the University of Arizona, it has become one of the most extensively published melanocortin receptor agonists in research literature, covering melanogenesis, central melanocortin circuits, and broad melanocortin pharmacology. The compound binds all five melanocortin receptors (MC1R through MC5R), with notable agonism at MC1R driving its prominent role in pigmentation pathway research.
Mechanism in research literature
Melanotan II is a pan-melanocortin agonist — its cyclic backbone enables high-affinity binding at MC1R (pigmentation pathway), MC3R/MC4R (hypothalamic melanocortin signalling), and MC5R (peripheral effects). In melanocyte culture studies, MT-II potently stimulates eumelanin synthesis through MC1R-coupled adenylyl cyclase activation. In hypothalamic neuronal cultures it modulates POMC-pathway signalling relevant to central melanocortin research. The breadth of receptor engagement is what makes MT-II a useful research probe — but also what distinguishes it from the more selective PT-141.
Documented research applications
Documented research contexts include melanocyte cell-culture studies, melanogenesis pathway assays, central melanocortin signalling research, and comparative melanocortin pharmacology. The compound's pan-receptor profile makes it a benchmark in melanocortin SAR (structure-activity relationship) research.
Reconstitution
Reconstitute lyophilised MT-II with bacteriostatic water. A common starting concentration is 10 mg/mL for a 10 mg vial in 1 mL BAC water. Swirl gently — do not shake — until fully dissolved.
Storage & stability
Store lyophilised MT-II at 2–8 °C. Reconstituted solution at 2–8 °C, used within 4 weeks.
Frequently asked questions
All Noxa Labs products are supplied strictly as analytical reference materials for qualified in vitro research. They are not pharmaceutical products, food supplements, or substances for human or animal consumption.
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